Department of Surgery

Finished

熱休克蛋白27與鈣離子通透管道因子STM1的調控在大腸癌上的進行及轉移上的角色探討

Wei, P.-L. (PI)

6/1/16 → 5/31/17

Project: C - Project of Alliance › p - Taipei Medical University Hospital

低氧在惡性神經膠瘤生成過程調控血管新生之機轉研究

Wang, W. (PI)

3/1/16 → 2/28/17

Project: C - Project of Alliance › o - Chi Mei Medical Center

水通道蛋白4在惡性神經膠細胞重排對血瘤障壁之影響研究

Tseng, Y.-Y. (PI)

3/1/16 → 2/28/17

Project: C - Project of Alliance › o - Chi Mei Medical Center

Functional Outcomes and Cognitive Interventions in Older People following Traumatic Brain Injury

Lin, M.-R. (PI), Tsai, S.-H. (CoI), Chen, S.-C. (CoI), Chiang, Y.-H. (CoI), Liou, T.-H. (CoI), Lin, Y.-N. (CoI) & Shu Kei Lam, C. (CoI)

1/1/16 → 12/31/16

Project: A - Government Institution › a - National Health Research Institutes

第二期癌症研究缺口補強研究計畫-大腸直腸癌之精準醫療研究發展-子計畫二

Wei, P.-L. (PI)

1/1/16 → 12/31/16

Project: A - Government Institution › c - Ministry of Health and Welfare

Establishing Health and Welfare Biotechnology Electronic Database Sharing Platform, Promoting Evidence-Based Medicine and Disseminating Technology Knowledge in Taiwan

Chen, C. (PI), Tam, K.-W. (CoI), Chen, K.-H. (CoI), Hou, W.-H. (CoI) & Bai, C.-H. (CoI)

1/1/16 → 12/31/16

Project: A - Government Institution › c - Ministry of Health and Welfare

In vitro, ex vivo and clinical characterization of novel Salmonella virulence genes

Fang, S.-B. (PI) & Huang, M.-T. (CoI)

1/1/16 → 12/31/16

Project: A - Government Institution › a - National Health Research Institutes

Studies on the Carcinogenic Mechanisms of Glucose Transporters in Gastrointestinal Cancer Cells and Its Clinical Therapeutic Applications

Chen, L.-C. (PI) & Wu, C.-H. (CoI)

9/1/15 → 8/31/16

Project: A - Government Institution › b - National Science and Technology Council

Characterization of Thalamocortical Dysrhythmia in Mild Traumatic Brain Injury Using Simultaneous Mri and Eeg Measurements and Pre-Clinical N-Acetylcysteine Treatment Response

Chen, C.-Y. (PI), Liu, H.-S. (CoI), Tseng, S.-H. (CoI), Lane, T. J. (CoI), Lu, C.-F. (CoI), Chiang, Y.-H. (CoI) & Tsai, P.-H. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Concurrent and Sequential Chemotherapy of Glioblastoma Multiforme in Rats Using Biodegradable Drug-Eluting Nanofibers

Tseng, Y.-Y. (PI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

HMGA2, a New Target of Thyroid Hormone-Induced Progression in Colorectal Cancers

Lin, H.-Y. (PI), Chang, T.-C. (CoI) & Yen, Y. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Dissected the Role of Glucose-Regulated Protein 94 (GRP94),The Clinically Therapeutic Implication and Drug Development in Colon Cancer

Wei, P.-L. (PI) & Chang, Y.-J. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

研究合併E1A基因和表皮生長因子受體酪氨酸激?抑制劑在三重陰性乳癌臨床前治療的嶄新策略(1/3)

Su, C.-M. (PI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Gene Knock out Mice Model for Studying the Molecular Mechanisms of Early Onset Breast Tumor Microenvironment Regulation.

Wu, C.-H. (PI), Ho, Y.-S. (CoI) & Tu, S.-H. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Genomic, Epigenomic and Epiproteomic Analysis of Etk/Bmx Traumatic Brain Injury

Chen, K.-Y. (PI), Chiang, Y.-H. (CoI) & Wu, C.-C. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Radiogenomics of Malignant Gliomas by Linking Physiological Mr Imaging, Histopathological Patterns, and Genetic Alternations: a Translational Study from Rat to Man

Chen, C.-Y. (PI), Tsai, P.-H. (CoI), Liu, H.-S. (CoI), Lin, Y.-H. (CoI) & Chiang, Y.-H. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Study of Expression and Functional Mechanisms of Histone 3 K4 Demethylase JARID1B in Tumorigenesis and Correlation with Progression in Lung Cancer

Kuo, K.-T. (PI), Wang, L.-S. (CoI) & Yeh, C.-T. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Repositioning Drug Therapies for Traumatic Brain Injury

Chiu, W.-T. (PI), Chang, C.-F. (CoI) & Chiang, Y.-H. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Study the Anti-Tumor Activity of E1A Gene Therapy---Focus on the Function and Biogenesis of microRNA

Chen, H.-A. (PI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation---The Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example

Ho, Y.-S. (PI) & Wu, C.-H. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

探討Dicer在胰臟癌細胞對gemcitabine感受性的影響及其調控機制(1/3)

Su, Y.-H. (PI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Application of Wearable Wireless Pulse Positioning System to Predict the Prognosis and to Avoid Sudden Death of Dialysis Patients

Kao, W.-F. (PI), Wu, M.-S. (CoI), Chen, R.-J. (CoI) & Chen, H.-H. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Study the Role of GRP78 in E1A-Mediated Metastasis Suppression of Breast Cancer

Wang, W. (PI) & Wu, C.-H. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Development of Novel Therapeutic Agents for Breast Cancer through Targeting Nicotinic Acetylcholine Receptors.

Wu, C.-H. (PI), Ho, Y.-S. (CoI) & Lee, C.-H. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › c - Ministry of Health and Welfare

The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model

Chang, C.-F. (PI) & Chiang, Y.-H. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Study the Function and Regulation of miRNAs in Pancreatic Cancer Progression (II)

Huang, M.-T. (PI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Functional Investigation of Heat Shock Protein in Esophageal Squamous Cell Cancer with Implications in Prognostic Prediction and Therapeutic Targeting

Tzao, C. (PI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

Chiang, Y.-H. (PI), Wu, C.-C. (CoI) & Lee, Y.-C. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

臺蒙(MN)國合計畫－以不同教學方法研究高級救命術教學對於蒙古國醫師之知識存留度之研究及其成效分析(2/3)

Ha, T.-C. (PI)

8/1/15 → 8/19/16

Project: A - Government Institution › b - National Science and Technology Council

Biomarkers for the Early Prediction and Prognosis for Colorectal Cancer---Construction of Kinetic

Chang, W.-C. (PI) & Wei, P.-L. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Development of Cortical Electrical Stimulation Technique for Improving Neuroplasticity and Motor Function in Parkinsonian Rats

Hsieh, T.-H. (PI), Chiang, Y.-H. (CoI) & Peng, C.-W. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

An Investigation of the Effects of Tea Component on the Inhibition of Leukocyte Nicotinic Acetylcholine Receptor Expression on Breast Cancer Patients

Tu, S.-H. (PI) & Wu, C.-H. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Effect of HMGA2 in Chemotherapy Response of Colorectal Cancer Patients with Different APC Status (II)

Yen, Y. (PI), Cheng, Y.-W. (CoI) & Wei, P.-L. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Translational Investigation for Tea Attenuate Smoking-Induced Disease---Breast Cancer and Atherosclerosis as a Mechanistic Study

Ho, Y.-S. (PI) & Wu, C.-H. (CoI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

探討Hsp27在大腸癌的進行、轉移能力與治療上的角色及其作用機制

Wei, P.-L. (PI)

5/1/15 → 4/30/16

Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

探討腫瘤抑制分子FOXO3a在胰臟癌gemcitabine抗藥性的角色

Chen, H.-A. (PI)

5/1/15 → 4/30/16

Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

探討乳酸去氫?對胰臟癌Gemcitabine抗藥性的調控與影響

Huang, M.-T. (PI)

5/1/15 → 4/30/16

Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

低氧調控多型性神經膠母細胞瘤遷移與侵襲之研究

Wang, W. (PI)

3/1/15 → 2/29/16

Project: C - Project of Alliance › o - Chi Mei Medical Center

使用超音波導引腹橫肌平面神經阻斷術於減重手術後之止痛作用

Tam, K.-W. (PI)

3/1/15 → 6/30/16

Project: C - Project of Alliance › o - Chi Mei Medical Center

低氧在多型性神經膠母細胞瘤生成過程調控血管新生之機轉研究

Tseng, Y.-Y. (PI)

3/1/15 → 2/29/16

Project: C - Project of Alliance › o - Chi Mei Medical Center

In vitro, ex vivo and clinical characterization of novel Salmonella virulence genes

Fang, S.-B. (PI) & Huang, M.-T. (CoI)

1/1/15 → 12/31/15

Project: A - Government Institution › a - National Health Research Institutes

Functional Outcomes and Cognitive Interventions in Older People following Traumatic Brain Injury

Lin, M.-R. (PI), Tsai, S.-H. (CoI), Chen, S.-C. (CoI), Chiang, Y.-H. (CoI), Liou, T.-H. (CoI), Lin, Y.-N. (CoI) & Shu Kei Lam, C. (CoI)

1/1/15 → 12/31/15

Project: A - Government Institution › a - National Health Research Institutes

TMU103-AE1-B16

Tzao, C. (PI)

1/1/15 → 12/31/15

Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

Promoting and Establishing Technology Exchange of Evidence-Based Medicine and Knowledge Sharing of Electronic Database in Taiwan

Chen, C. (PI), Tam, K.-W. (CoI), Chen, K.-H. (CoI), Hou, W.-H. (CoI) & Bai, C.-H. (CoI)

1/1/15 → 12/31/15

Project: A - Government Institution › c - Ministry of Health and Welfare

北區高階生醫產業聚落及產業規劃-台灣遠距健康產業聚落發展先導計畫

Yen, Y. (PI) & Chen, R.-J. (CoI)

9/1/14 → 8/31/15

Project: A - Government Institution › c - Ministry of Health and Welfare

Valproate治療腦外傷病人的臨床研究

Chang, C.-F. (PI), Chiang, Y.-H. (CoI), Liao, K.-H. (CoI), Yang, S.-T. (CoI), Wu, C.-C. (CoI) & Chen, K.-Y. (CoI)

8/7/14 → 8/6/16

Project: A - Government Institution › c - Ministry of Health and Welfare

Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation: the Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example.

Ho, Y.-S. (PI) & Wu, C.-H. (CoI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

An Investigation of the Effects of Tea Component on the Inhibition of Leukocyte Nicotinic Acetylcholine Receptor Expression on Breast Cancer Patients

Tu, S.-H. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標：目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色目標二：研究E1A抑制GRP78表現之分子機轉目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

Wang, W. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Determined the Role and the Mechanims of GRP94 in Mediating the Progression and Therapeutic Responses of HCC

Huang, M.-T. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Department of Surgery

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