Department of Pharmacology

2014

Energy adaptive response during parthanatos is enhanced by PD98059 and involves mitochondrial function but not autophagy induction

Huang, C. T., Huang, D. Y., Hu, C. J., Wu, D. & Lin, W.-W., Mar 2014, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 3, p. 531-543 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Citations (Scopus)

Extract of antrodia camphorata exerts neuroprotection against embolic stroke in rats without causing the risk of hemorrhagic incidence

Lee, Y. M., Chang, C. Y., Yen, T. L., Geraldine, P., Lan, C. C., Sheu, J. R. & Lee, J. J., 2014, In: Scientific World Journal. 2014, 686109.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Ex vivo and in vivo studies of CME-1, a novel polysaccharide purified from the mycelia of Cordyceps sinensis that inhibits human platelet activation by activating adenylate cyclase/cyclic AMP

Lu, W.-J., Chang, N. C., Jayakumar, T., Liao, J. C., Lin, M. J., Wang, S. H., Chou, D. S., Thomas, P. A. & Sheu, J. R., Dec 1 2014, In: Thrombosis Research. 134, 6, p. 1301-1310 10 p.

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Hinokitiol is a novel glycoprotein VI antagonist on human platelets

Lu, W.-J., Wu, M. P., Lin, K. H., Lin, Y. C., Chou, H. C. & Sheu, J. R., Dec 1 2014, In: Platelets. 25, 8, p. 595-602 8 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Histone deacetylase inhibitor impairs plasminogen activator inhibitor-1 expression via inhibiting TNF-α-activated MAPK/AP-1 signaling cascade

Chen, W. L., Sheu, J. R., Hsiao, C. J., Hsiao, S. H., Chung, C. L. & Hsiao, G., 2014, In: BioMed Research International. 2014, 231012.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Citations (Scopus)

How did national life expectation related to school years in developing countries-An approach using panel data mining

Jian, W. S., Huang, C. L., Iqbal, U., Nguyen, P. A., Hsiao, G. & Li, H. C., Mar 2014, In: Computer Methods and Programs in Biomedicine. 113, 3, p. 914-918 5 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Mechanisms of ascorbyl radical formation in human platelet-rich plasma

Shyu, K.-G., Chang, C. C., Yeh, Y. C., Sheu, J. R. & Chou, D. S., 2014, In: BioMed Research International. 2014, 614506.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

Multidrug resistance protein 4 (MRP4/ABCC4) regulates thrombus formation in vitro and in vivo

Lien, L. M., Chen, Z. C., Chung, C. L., Yen, T. L., Chiu, H. C., Chou, D. S., Huang, S. Y., Sheu, J. R., Lu, W.-J. & Lin, K. H., Aug 15 2014, In: European Journal of Pharmacology. 737, p. 159-167 9 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Novel drugs development for cardio-/cerebrovascular diseases

Sheu, J. R., Thomas, P. A. & Cheng, J. T., 2014, In: BioMed Research International. 2014, 467936.

Research output: Contribution to journal › Editorial › peer-review

Open Access

7 Citations (Scopus)

Novel piperazinediones as antitumor agents

Wang, C. L., Lee, O., Hsiao, G., Lian, J. F. & Cheng, Y. W., Aug 1 2014, In: Anticancer Research. 34, 8, p. 4013-4020 8 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Pharmacology and clinical effect of platonin, a cyanine photosensitizing dye: Potential molecular targets

Lee, J. J., Chang, C. F., Sheu, J. R. & Jayakumar, T., Jan 1 2014, In: Current Pharmaceutical Biotechnology. 15, 8, p. 700-711 12 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

PMC, a potent hydrophilic α-tocopherol derivative, inhibits NF-κB activation via PP2A but not IκBα-dependent signals in vascular smooth muscle cells

Hsieh, C. Y., Hsiao, G., Hsu, M. J., Wang, Y. H. & Sheu, J. R., Jul 2014, In: Journal of Cellular and Molecular Medicine. 18, 7, p. 1278-1289 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

Potential advantages of Chinese medicine Taohong Siwu Decoction (桃红四物汤) combined with tissue-plasminogen activator for alleviating middle cerebral artery occlusion-induced embolic stroke in rats

Yen, T. L., Ong, E. T., Lin, K. H., Chang, C. C., Jayakumar, T., Lin, S. C., Fong, T. H. & Sheu, J. R., Sept 24 2014, (E-pub ahead of print) In: Chinese Journal of Integrative Medicine. p. 1-14 14 p.

Research output: Contribution to journal › Article › peer-review

Pulmonary air crescent sign

Lee, K. L., Liang, H. H., Chung, C. L., Hsiao, S. H. & Shih, C. H., Jan 2014, In: JAMA Surgery. 149, 1, p. 97-98 2 p.

Research output: Contribution to journal › Short survey › peer-review

1 Citation (Scopus)

Role of a Janus kinase 2-dependent signaling pathway in platelet activation

Lu, W.-J., Lin, K. C., Huang, S. Y., Thomas, P. A., Wu, Y. H., Wu, H. C., Lin, K. H. & Sheu, J. R., 2014, In: Thrombosis Research. 133, 6, p. 1088-1096 9 p.

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Src contributes to IL6-induced vascular endothelial growth factor-C expression in lymphatic endothelial cells

Huang, Y. H., Yang, H.-Y., Hsu, Y. F., Chiu, P. T., Ou, G. & Hsu, M.-J., Apr 1 2014, In: Angiogenesis. 17, 2, p. 407-418 12 p.

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

The effects of funoran-containing xylitol chewing gum on dental plaque

Wang, M. J., Chang, W. J., Lee, W. F., Lee, S. Y., Sheu, J. R. & Teng, N. C., May 1 2014, In: Journal of Polymer Engineering. 34, 3, p. 203-208 6 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells

Chuang, Y. F., Yang, H. Y., Ko, T. L., Hsu, Y. F., Sheu, J. R., Ou, G. & Hsu, M. J., Apr 1 2014, In: Biochemical Pharmacology. 88, 3, p. 372-383 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Citations (Scopus)

2013

Andrographolide, a novel NF- B inhibitor, induces vascular smooth muscle cell apoptosis via a ceramide-p47phox-ROS signaling cascade

Chen, Y. Y., Hsu, M. J., Sheu, J. R., Lee, L. W. & Hsieh, C. Y., 2013, In: Evidence-based Complementary and Alternative Medicine. 2013, 821813.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Citations (Scopus)

A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: Ex vivo and in vivo studies

Jayakumar, T., Chen, W. F., Lu, W.-J., Chou, D. S., Hsiao, G., Hsu, C.-Y., Sheu, J. R. & Hsieh, C. Y., Jun 2013, In: Journal of Nutritional Biochemistry. 24, 6, p. 1086-1095 10 p.

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

A novel bioactivity of andrographolide from Andrographis paniculata on cerebral ischemia/reperfusion-induced brain injury through induction of cerebral endothelial cell apoptosis

Yen, T. L., Hsu, W. H., Huang, S. K. H., Lu, W.-J., Chang, C. C., Lien, L. M., Hsiao, G., Sheu, J. R. & Lin, K. H., Sept 2013, In: Pharmaceutical Biology. 51, 9, p. 1150-1157 8 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Anti-cancer activity of an osthole derivative, NBM-T-BMX-OS01: Targeting vascular endothelial growth factor receptor signaling and angiogenesis

Yang, H. Y., Hsu, Y. F., Chiu, P. T., Ho, S. J., Wang, C. H., Chi, H. N., Huang, Y. H., Lee, C. F., Li, Y. S., Ou, G. & Hsu, M. J., Nov 27 2013, In: PLoS ONE. 8, 11, e81592.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Citations (Scopus)

Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human platelets.

Chang, Y., Huang, S. K. H., Lu, W. J., Chung, C. L., Chen, W. L., Lu, S. H., Lin, K. H. & Sheu, J. R., Jan 25 2013, In: Unknown Journal. 20, p. 4 1 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entry

Lin, L. T., Chen, T. Y., Lin, S.-C., Chung, C. Y., Lin, T. C., Wang, G. H., Anderson, R., Lin, C. C. & Richardson, C. D., 2013, In: BMC Microbiology. 13, 1, 187.

Research output: Contribution to journal › Article › peer-review

Open Access

169 Citations (Scopus)

Cinnamophilin isolated from cinnamomum philippinense protects against collagen degradation in human chondrocytes

Lu, Y. C., Hsiao, G., Lin, K. H., Hsieh, M.-S., Jayakumar, T., Wu, T. S. & Sheu, J. R., Jun 2013, In: Phytotherapy Research. 27, 6, p. 892-899 8 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Clinical Importance of Angiogenic Cytokines, Fibrinolytic Activity and Effusion Size in Parapneumonic Effusions

Chung, C. L., Hsiao, S. H., Hsiao, G., Sheu, J. R., Chen, W. L. & Chang, S. C., Jan 7 2013, In: PLoS ONE. 8, 1, e53169.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

Connective tissue growth factor induces collagen I expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway

Lin, C. H., Yu, M. C., Tung, W. H., Chen, T. T., Yu, C. C., Weng, C. M., Tsai, Y. J., Bai, K. J., Hong, C. Y., Chien, M. H. & Chen, B. C., Dec 2013, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 12, p. 2823-2833 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Citations (Scopus)

Denbinobin induces human glioblastoma multiforme cell apoptosis through the IKKα-Akt-FKHR signaling cascade

Weng, H. Y., Hsu, M. J., Chen, C. C., Chen, B. C., Hong, C. Y., Teng, C. M., Pan, S. L., Chiu, W. T. & Lin, C. H., Jan 5 2013, In: European Journal of Pharmacology. 698, 1-3, p. 103-109 7 p.

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Distinct clinical outcomes of non-small cell lung cancer patients with Epidermal Growth Factor Receptor (EGFR) mutations treated with EGFR tyrosine kinase inhibitors: Non-responders versus responders

Hsiao, S. H., Liu, H. E., Lee, H. L., Lin, C. L., Chen, W. Y., Wu, Z. H., Lin, S. E., Chiang, L. L. & Chung, C. L., Dec 23 2013, In: PLoS ONE. 8, 12, e83266.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

Effect of Epigallocatechin Gallate on Markers of Inflammation

Geraldine, P., Elango, R., Theodore, J., Sheu, J. R. & Thomas, P. A., Jan 1 2013, Tea in Health and Disease Prevention. Elsevier, p. 1223-1237 15 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

ENdothelin-1 in inflammatory and malignant pleural effusions

Chung, C.-L., Chen, W.-L., Hsiao, S.-H. & Hsiao, G., Oct 1 2013, In: Chest. 144, 4_MeetingAbstracts, p. 516A-516A

Research output: Contribution to journal › Meeting Abstract › peer-review

Experimental and clinical pharmacology of andrographis paniculata and its major bioactive phytoconstituent andrographolide

Jayakumar, T., Hsieh, C. Y., Lee, J. J. & Sheu, J. R., 2013, In: Evidence-based Complementary and Alternative Medicine. 2013, 846740.

Research output: Contribution to journal › Review article › peer-review

Open Access

251 Citations (Scopus)

Hinokitiol, a natural tropolone derivative, offers neuroprotection from thromboembolic stroke in vivo

Jayakumar, T., Hsu, W. H., Yen, T. L., Luo, J. Y., Kuo, Y. C., Fong, T. H. & Sheu, J. R., 2013, In: Evidence-based Complementary and Alternative Medicine. 2013, 840487.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Citations (Scopus)

Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo

Lin, K. H., Kuo, J. R., Lu, W.-J., Chung, C. L., Chou, D. S., Huang, S. Y., Lee, H. C. & Sheu, J. R., May 15 2013, In: Biochemical Pharmacology. 85, 10, p. 1478-1485 8 p.

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Histological subtype and smoking status, but not gender, are associated with epidermal growth factor receptor mutations in non-small‑cell lung cancer

Hsiao, S. H., Lin, S.-E., Chou, Y. T., Wang, J.-L., Chung, C.-L., Yu, M.-C., Fang, C.-L., Lee, H. L., Chiang, L.-L., Liu, H.-E. & Wu, C. W., Dec 23 2013, In: Molecular and Clinical Oncology. 2, p. 252-258 7 p.

Research output: Contribution to journal › Article › peer-review

File

47 Downloads (Pure)

HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation

Liao, Y. H., Lin, Y. C., Tsao, S. T., Lin, Y. C., Yang, A. J., Huang, C. T., Huang, K. C. & Lin, W. W., Feb 8 2013, In: Journal of Leukocyte Biology. 93, 2, p. 289-299 11 p.

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Identification of subgroup patients with stage IIIB/IV non-small cell lung cancer at higher risk for brain metastases

Hsiao, S. H., Chung, C. L., Chou, Y. T., Lee, H. L., Lin, S. E. & Liu, H. E., Nov 2013, In: Lung Cancer. 82, 2, p. 319-323 5 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

IL-22 activates oxidant signaling in pulmonary vascular smooth muscle cells

Bansal, G., Das, D., Hsieh, C. Y., Wang, Y. H., Gilmore, B. A., Wong, C. M. & Suzuki, Y. J., Dec 2013, In: Cellular Signalling. 25, 12, p. 2727-2733 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Citations (Scopus)

Impact of epidermal growth factor receptor mutations on intracranial treatment response and survival after brain metastases in lung adenocarcinoma patients

Hsiao, S. H., Lin, H. C., Chou, Y. T., Lin, S. E., Kuo, C. C., Yu, M. C. & Chung, C. L., Sept 2013, In: Lung Cancer. 81, 3, p. 455-461 7 p.

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Inhibitory effect of midazolam on MMP-9, MMP-1 and MMP-13 expression in PMA-stimulated human chondrocytes via recovery of NF-κB signaling

Wang, J. J., Huan, S. K. H., Hsieh, K. H., Chou, H. C., Hsiao, G., Jayakumar, T. & Sheu, J. R., Apr 2013, In: Archives of Medical Science. 9, 2, p. 332-339 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Citations (Scopus)

Inhibitory effects of hesperetin derivatives on guinea pig phosphodiesterases and Their ratios between high- and low-affinity rolipram binding

Hsu, H. T., Wang, W. H., Han, C. Y., Chen, C. N., Chen, C. M. & Ko, W.-C., Jul 2013, In: Journal of Pharmaceutical Sciences. 102, 7, p. 2120-2127 8 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Mechanisms of andrographolide-induced platelet apoptosis in human platelets: Regulatory roles of the extrinsic apoptotic pathway

Lien, L.-M., Su, C. C., Hsu, W. H., Lu, W.-J., Chung, C.-L., Yen, T. L., Chiu, H. C., Sheu, J.-R. & Lin, K. H., Nov 2013, In: Phytotherapy Research. 27, 11, p. 1671-1677 7 p.

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Notch Ligand Delta-Like 4-Pretreated Dendritic Cells Alleviate Allergic Airway Responses by Enhancing IL-10 Production

Huang, H. M., Hsiao, G., Fan, C. K., Lin, C. L., Leu, S. J., Chiang, B. L. & Lee, Y. L., May 16 2013, In: PLoS ONE. 8, 5, e63613.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)

Novel bioactivity of ellagic acid in inhibiting human platelet activation

Chang, Y., Chen, W. F., Lin, K. H., Hsieh, C. Y., Chou, D. S., Lin, L. J., Sheu, J. R. & Chang, C. C., 2013, In: Evidence-based Complementary and Alternative Medicine. 2013, 595128.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Citations (Scopus)

Platelet protease-activated receptor (PAR)4, but not PAR1, associated with neutral sphingomyelinase responsible for thrombin-stimulated ceramide-NF-κB signaling in human platelets

Chen, W. F., Lee, J. J., Chang, C. C., Lin, K. H., Wang, S. H. & Sheu, J. R., May 2013, In: Haematologica. 98, 5, p. 793-801 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Citations (Scopus)

Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade

Chang, H. L., Chen, C. Y., Hsu, Y. F., Kuo, W. S., Ou, G., Chiu, P. T., Huang, Y. H. & Hsu, M. J., 2013, In: Biochimica et Biophysica Acta - General Subjects. 1830, 8, p. 4053-4064 12 p.

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Suitability of computed tomography-guided biopsy specimens for subtyping and genotyping of non-small-cell lung cancer

Hsiao, S. H., Chung, C. L., Lee, C.-M., Chen, W. Y., Chou, Y. T., Wu, Z. H., Chen, Y. C. & Lin, S. E., Nov 2013, In: Clinical Lung Cancer. 14, 6, p. 719-725 7 p.

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

The role of cyclooxygenase-derived oxidative stress in surgically induced lymphedema in a mouse tail model

Chang, T. C., Uen, Y. H., Chou, C. H., Sheu, J. R. & Chou, D. S., May 2013, In: Pharmaceutical Biology. 51, 5, p. 573-580 8 p.

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Thrombin-induced CCN2 expression in human lung fibroblasts requires the c-Src/ JAK2/STAT3 pathway

Bai, K. J., Chen, B. C., Pai, H. C., Weng, C. M., Yu, C. C., Hsu, M. J., Yu, M. C., Ma, H. P., Wu, C. H., Hong, C. Y., Kuo, M. L. & Lin, C. H., Jan 2013, In: Journal of Leukocyte Biology. 93, 1, p. 101-112 12 p.

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Virally inactivated human platelet concentrate lysate induces regulatory T cells and immunosuppressive effect in a murine asthma model

Lee, Y. L., Lee, L. W., Su, C. Y., Hsiao, G., Yang, Y. Y., Leu, S. J., Shieh, Y. H. & Burnouf, T., Sept 2013, In: Transfusion. 53, 9, p. 1918-1928 11 p.

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Department of Pharmacology

Research output

Search results