Projects per year
- 750 - 800 out of 3,058 results
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An Investigation of the Effects of Tea Component on the Inhibition of Leukocyte Nicotinic Acetylcholine Receptor Expression on Breast Cancer Patients
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Study the Therapeutic Effects and Novel Molecular Mechanisms of Resveratrol in Human Osteosarcoma---The Treatment of Metastatic Cancer
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Evaluation of Clinical Feasibility of Quantitative MR Perfusion Imaging and Its Calibration
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation on Developing Novel Biomarkers and Treatments in the Patients with Fibromyalgia
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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TMU102-AE1-B45
7/1/14 → 7/31/15
Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty
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Molecular and Cellular Mechanism of Adipocyte Modulatory Effects on Pulmonary Vein and Atrium
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effect of Muscle Strength Training on Body Composition and Sarcopenic Obesity among the Female Overweight Elderly
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Haplo-Insufficiency of TSGs on Chromosome 2 for Paclitaxel-Resistant Phenotype of OCCA Cells
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Studies of Anti-Cancer Activity of Folic Acid
Lee, W.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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ALA Photodynamic Therapy, Tumor Hypoxia, CSE1L Phosphorylation, and the Progression and Treatment of Skin Cancer
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Application of Scaffold in Ovarian Transplantation for Female Fertility Preservation---An in vivo Transgenic Mouse Model (I)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Functional Role of Transcription Factor Sp1 in Brain Neuronal Injury (III)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Biomarkers Associated with Toll-Like Receptors and Neuroimage Study in Ischemic Stroke Patients (II)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Roles of Toll-Like Receptor-4 and Hif-1 in Propofol-Involved Protection against Traumatic Brain Injury-Induced Dysfunction of the Blood-Brain Barrier
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Arsenic Methylation Capacity, Methylenetetrahydrofolate Reductase and Dna Methylation Gene Polymorphisms, Plasma Selenium Concentration and Selenoprotein Gene Polymorphisms and Renal Cell Carcinoma
Hsueh, Y.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Can Sesamin Alone or Cotheapy with Anti-DM Medicines Alleviate the Abnormal Intermediate Metabolites of Glucose and Fatty Acids, the Oxygen Consumption and Renal Fibrotic Progression?
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs (III)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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以冥想治療與歌唱治療改善巴金森症患自律神經功能之研究
1/1/14 → 7/31/15
Project: C - Project of Alliance › m - National Taiwan University of Science and Technology
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The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (II)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Analysis the Role of Satellite Cell during Denervation Induced Muscular Atrophy and a Trail of Transplantation of Adipocyte Derived Myogenic Stem Cells
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation: the Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example.
Ho, Y. & Wu, C.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation of Glioblastoma Cell-Secreted microRNA Signatures and Their Functional Effects on Tumor Angiogenesis
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Evaluation of the Mechanism of Post-Traumatic Immunosuppression---The Role of TLR4 Trafficking and microRNA
Lin, J. A.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Novel Roles of Aldose Reductase (AR) in Collagen GPVI- and Thrombin PAR4-Mediated Platelet Activation and Apoptosis---Regulatory Machinery of Arf-AR Signaling in Anucleate Cells
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Role and Molecular Mechanism of PPARα in Acute Kidney Injury---Focus on the Protective Effect in Renal Tubular Cell
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Relationship between Lumbar Vertebral Perfusion and Fat Marrow Content in Normal Subjects, Osteoporosis and Bone Metastases Using DCE-MRI and Fat-Water Separation
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Characterization of 5-Hydroxymethylcytosine and Ten-to-Eleven Translocation Gene (TET) in Cervical Cancer
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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肝醣合成酉每激酉每3於登革病毒感染單核吞噬細胞的潛在角色(2/3)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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氧化還原作用調控蛋白質去磷酸酉每羰基化和去羰基化反應對動脈血管內膜增生之影響(1/2)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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探討NLRP12調控病毒引起免疫反應之機轉(1/3)
Chen, S.
8/1/15 → 8/1/15
Project: A - Government Institution › b - Ministry of Science and Technology
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人類 ZFP36L1與ZFP36L2蛋白質在抗病毒機制之研究(1/2)
Lin, R.
8/1/15 → 8/5/15
Project: A - Government Institution › b - Ministry of Science and Technology
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TGF-beta誘導人類大腸癌細胞CTGF表現之機轉研究
6/1/14 → 8/31/15
Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital
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北區高階生醫產業聚落及產業規劃-台灣遠距健康產業聚落發展先導計畫
9/1/14 → 8/31/15
Project: A - Government Institution › c - Ministry of Health and Welfare
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Chitosan Nanoparticle as a Macrophage-Targeting Drug Delivery Carrier
8/1/14 → 8/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Study of glycosyl hydrolase and carbohydrate interaction by silicon nanowire effect
1/1/14 → 9/30/15
Project: C - Project of Alliance › j - National Taipei University of Technology
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TMU103-AE1-B03
10/1/14 → 9/30/15
Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty
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Differential Machinery of Pluripotency Regulation in Stem Cells in Embryonic Stage and Somatic Cancers and Its Clinical Implications in Human Diseases---Crosstalk among Niche Growth Factor/Cytokine Signaling, Extracellular Matrix, and Epigenetic Netw (I)
10/1/14 → 9/30/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Study the Interactive Functions of Decoy Receptor 3 and Galectin-3 in Keratinocytes and Macrophages
Lin, W.
10/1/14 → 9/30/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Developing Human Intestinal in vitro Organ Culture and an in vitro M-Cell Model as Platforms for Investigation of Novel Oral Vaccines
8/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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TMU103-AE1-B08
11/1/14 → 10/31/15
Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty
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經表皮塗抹硝酸甘油軟膏於痔瘡切除術後之止痛作用
3/1/14 → 10/31/15
Project: C - Project of Alliance › s - Shin Kong Wu Ho-Su Memorial Hospital
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A Study on Trans-Neuronal Striato-Nigral Degeneration-Induced Movement Disorders after Stroke---Evaluation with Grey Matter Suppression Ir and Diffusion Tensor Imaging (III)
8/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Down-Regulation of RanGAP Augments Nucleus BCR-ABL Level to Potentiate the Drug Efficacy of Imatinib in Chronic Myelogenous Leukemia
8/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Analyze Exhaled Gas of COPD Patients( I )
5/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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TMU103-AE1-B05
11/1/14 → 10/31/15
Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty
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Translational Studies of Mycobacterium tuberculosis-Induced Lung and Pleural Fibrosis
8/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Optimization of Human Meniscus Imaging and Its Clinical Application for Osteoarthritis (II)
Tsai, P.
8/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Mechanisms Underlying Airway Hypersensitivity Induced by Hydrogen Sulfide
8/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology