College of Medical Science and Technology

Projects

Projects per year 2010 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2024

• 73 Active
• 1019 Finished

Projects per year

Search results

• Reduced microRNA-184 by E6 oncoprotein confers cisplatin resistance in lung cancer via increasing Bcl-2

  Lee, H.

  2/1/16 → 1/31/17

  Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital

• Repositioning Drug Therapies for Traumatic Brain Injury

  Chiu, W., Chang, C. & Chiang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Traumatic Brain Injury 100%
  • Wounds and Injuries 37%
  • Dipeptidyl-Peptidase IV Inhibitors 33%
  • Incretins 33%
  • Acetylcysteine 28%

• Role of Androgen on Breast Cancer Development and Treatment

  Lin, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Androgen 100%
  • Testosterone 31%
  • Signal Transduction 21%
  • Chemopreventive 9%
  • Silencing RNA 8%

• Role of Huntingtin-Associated Protein on Microtubule-Dependent Trafficking in Mice

  Lin, Y.

  1/1/11 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Huntingtin Protein 100%
  • Microtubules 29%
  • Microtubule Proteins 10%
  • Neurites 8%
  • Huntington Disease 8%

• Role of miR-21 in Regulating TET I-Hydroxymethylcytosine and Chemotherapeutic Response in Colorectal Cancer (I)

  Yang, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colorectal Neoplasms 100%
  • 5-hydroxymethylcytosine 84%
  • APC Genes 58%
  • DNA Methylation 55%
  • Adenomatous Polyposis Coli 51%

• Role of miR-21 in Regulating TET I-Hydroxymethylcytosine and Chemotherapeutic Response in Colorectal Cancer (II)

  Yang, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Normoxic Expression of Hypoxia Inducible Factor 1-Α and Endoplasmic Reticulum Stress Associated Protein GRP78 in the Modulation of Drug and Radioresistance Acquisition of Human Hepatoma Cell Lines

  Chiou, J. & Wu, A. T.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hypoxia-Inducible Factor 1 100%
  • 1-phenyl-3,3-dimethyltriazene 55%
  • Reticulum 33%
  • Research Design 31%
  • Paclitaxel 26%

• Role of Normoxic Expression of Hypoxia Inducible Factor 1-Α and Endoplasmic Reticulum Stress Associated Protein Grp-78 in the Modulation of Drug-And Radioresistance Acquisition of Human Hepatoma Cell Lines

  Chiou, J. & Wu, A. T.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hypoxia-Inducible Factor 1 100%
  • 1-phenyl-3,3-dimethyltriazene 55%
  • Reticulum 33%
  • Research Design 31%
  • Paclitaxel 26%

• Role of Ribonucleotide Reductase (Rnr) in Skeletal Muscle with Age: the Functionality of Rrm2b in Repair and Regeneration

  Chen, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Skeletal Muscle 100%
  • Sarcopenia 58%
  • Regeneration 52%
  • Muscles 47%
  • Muscular Diseases 33%

• Role of Ribonucleotide Reductase (Rnr) in Skeletal Muscle with Age: the Functionality of Rrm2b in Repair and Regeneration

  Chen, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Skeletal Muscle 100%
  • Sarcopenia 58%
  • Regeneration 52%
  • Muscles 47%
  • Muscular Diseases 33%

• Role of Ribonucleotide Reductase (Rnr) in Skeletal Muscle with Age: the Functionality of Rrm2b in Repair and Regeneration

  Chen, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Skeletal Muscle 100%
  • Sarcopenia 58%
  • Regeneration 52%
  • Muscles 47%
  • Muscular Diseases 33%

• Role of Rrm2b in the Interplay between Stem Cells and Niche of Skeletal Muscle to Regulate Muscle Regeneration with Age

  Chen, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of Hdac6-Mediated Sp1 Deacetylation in the Evolution of Acquired Temozolomide Resistance in Glioblastoma

  Chuang, J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone Deacetylase 6 100%
  • Temozolomide 84%
  • Glioblastoma 54%
  • Vorinostat 26%
  • Methyltransferases 20%

• Roles of microRNA96 in TGF-beta-Mediated Tumor Progression

  Tsai, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Transforming Growth Factors 100%
  • Neoplasms 26%
  • Prostatic Neoplasms 21%
  • Castration 15%
  • Androgen Receptors 14%

• Roles of microRNA96 in TGF-beta-Mediated Tumor Progression(2/3)

  Tsai, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Transforming Growth Factors 100%
  • Neoplasms 26%
  • Prostatic Neoplasms 21%
  • Castration 15%
  • Androgen Receptors 14%

• Roles of Microrna96 in Tgfβ-Mediated Tumor Progression

  Tsai, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Transforming Growth Factors 100%
  • Neoplasms 26%
  • Prostatic Neoplasms 21%
  • Castration 15%
  • Androgen Receptors 14%

• RRM2 在帶有不同APC 及k-ras 基因突變情形之大腸直腸癌轉移及治療效果所扮演的角色

  Cheng, Y.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Smart Mouth Guard 3D Drug Delivery and Wound Dressing Device Development (Project 1)

  Deng, W. & Ou, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mouth Protectors 100%
  • Bandages 50%
  • Equipment and Supplies 38%
  • Pharmaceutical Preparations 26%
  • Periodontitis 26%

• Smokefreebrain: Multidisciplinary Tools for Improving the Efficacy of Public Prevention Measures against Smoking

  Shabbir, S. A.

  5/1/18 → 4/30/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Smokefreebrain: Multidisciplinary Tools for Improving the Efficacy of Public Prevention Measures against Smoking( I )

  Shabbir, S. A.

  5/1/17 → 4/30/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Structural and Functional Studies on the Virulence Regulators SaeR/S in Staphylococcus aureus

  Liu, C.

  12/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Staphylococcus aureus 100%
  • virulence 52%
  • immune evasion 23%
  • sepsis (infection) 23%
  • histidine kinase 21%

• Structure-Based Design, Synthesis and Biological Evaluation of Novel 6-Substituted 10-Chloro-12h-Thiochromeno[2,3-C]Quinolin-12-One Derivatives as Potential Anticancer Agents

  Huang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Antineoplastic Agent 100%
  • Intoplicine 80%
  • Molecule 65%
  • Topoisomerase Inhibitor 63%
  • Growth Inhibition 44%

• Studies of Prostate Cancer Progression after Androgen-Deprivation Therapy and Development of Cancer Immunotherapy via Anti-Inflammation Approaches

  Tsai, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Androgen Receptors 100%
  • Prostatic Neoplasms 61%
  • Inflammation 54%
  • Androgens 42%
  • Neoplasms 39%

• Studies of Roles of SIRT7 in Cancer Biology

  Tsai, Y.

  1/1/14 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • neoplasms 100%
  • neoplasm cells 59%
  • Biological Sciences 47%
  • cancer therapy 31%
  • drug development 27%

• Studies of the Anti-Tumoral Mechanisms of Proteasome Inhibitor by Proteomic Techniques

  Liang, Y.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Bortezomib 100%
  • Heterogeneous-Nuclear Ribonucleoprotein K 63%
  • 14-3-3 Proteins 45%
  • Burkitt Lymphoma 39%
  • Protein Biosynthesis 29%

• Studies of the Anti-Tumoral Mechanisms of Proteasome Inhibitor by Proteomic Techniques

  Liang, Y.

  7/31/11 → 7/30/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Bortezomib 100%
  • Heterogeneous-Nuclear Ribonucleoprotein K 63%
  • 14-3-3 Proteins 45%
  • Burkitt Lymphoma 39%
  • Protein Biosynthesis 29%

• Studies on the Carcinogenic Mechanisms of Histamine N-Methyltransferase-Mediated Breast Cancer Formation

  Wu, C. & Ho, Y.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Breast Neoplasms 19%
  • Neoplasms 7%
  • Carcinogenesis 6%

• Studies on the Mechanisms of a9-Nicotinic Acetylcholine Receptor Confers Tamoxifen-Induced Drug Resistance in Human Breast Cancer Cells

  Ho, Y. & Wu, C.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Phosphopyruvate Hydratase 100%
  • Nicotinic Receptors 46%
  • Breast Neoplasms 44%
  • Drug Resistance 31%
  • Nicotine 23%

• Studies on the Mechanisms of A9-Nicotinic Acetylcholine Receptor Confers Tamoxifen-Induced Drug Resistance in Human Breast Cancer Cells

  Ho, Y. & Wu, C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Phosphopyruvate Hydratase 100%
  • Nicotinic Receptors 46%
  • Breast Neoplasms 44%
  • Drug Resistance 31%
  • Nicotine 23%

• Studies on the Mechanisms of Apple Polyphenol (Phloretin)-Induced Apoptosis in Human Breast Cancer Cells

  Wu, C. & Ho, Y.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glucose 100%
  • Antitumor 17%
  • Laser Capture Microdissection 12%
  • Phloretin 7%
  • Apoptosis Induction 7%

• Studies on the Mechanisms of Histamine N-Methyl-Transferase (Hnmt) as a Novel Molecular Marker to Help Clinician for Identifying of Herceptin Responder in Breast Cancer Patients(1/3)

  Ho, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Mechanisms of Histamine N-Methyltransferase (Hnmt)-Mediated Herceptinr Drug-Resistance in Breast Cancer Cells

  Ho, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Trastuzumab 89%
  • Breast Neoplasms 17%
  • Tissue Array Analysis 9%
  • Gene Expression Profiling 8%

• Studies on the Mechanisms of Histamine N-Methyltransferase (Hnmt)-Mediated Herceptinr Drug-Resistance in Breast Cancer Cells

  Ho, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Trastuzumab 89%
  • Breast Neoplasms 17%
  • Tissue Array Analysis 9%
  • Gene Expression Profiling 8%

• Studies on the Mechanisms of Histamine N-Methyltransferase (Hnmt)-Mediated Herceptinr Drug-Resistance in Breast Cancer Cells(3/3)

  Ho, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Trastuzumab 89%
  • Breast Neoplasms 16%
  • Tissue Array Analysis 9%
  • Gene Expression Profiling 8%

• Study and Implementation of Patient Privacy Protection under the Framework for Electronic Medical Records Exchange in Taiwan

  Liu, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Electronic medical equipment 100%
  • Data privacy 38%
  • Health insurance 14%
  • Virtual private networks 13%
  • Law enforcement 10%

• Study a Novel Klf10 (Kruppel-Like Transcription Factor10) Regulated Mechanism in Non-Alcoholic Fatty Liver Disease (NAFLD)

  Chang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Non-alcoholic Fatty Liver Disease 100%
  • AMP-Activated Protein Kinases 80%
  • Sterol Regulatory Element Binding Protein 1 57%
  • Lipid Metabolism 32%
  • Type 2 Diabetes Mellitus 19%

• Study a Novel Klf10 (Kruppel-Like Transcription Factor10) Regulated Mechanism in Non-Alcoholic Fatty Liver Disease (Nafld) (Continued Project)

  Chang, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Non-alcoholic Fatty Liver Disease 100%
  • AMP-Activated Protein Kinases 97%
  • Sterol Regulatory Element Binding Protein 1 79%
  • Lipid Metabolism 33%
  • Fatty Liver 24%

• Studying the mechanism of CCL5/RANTES in neuro protection in a brain injury mouse mode –memory neurite circuit activation after injury

  Chou, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Anti-RRM-2 Antibody Drug Generation and Their Inhibitory Mechanisms

  Yang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Antibodies 100%
  • Single-Chain Antibodies 93%
  • Anti-Idiotypic Antibodies 60%
  • Diphosphates 47%
  • human RRM2B protein 46%

• Study of Anti-Αlpha-Enolase I Antibodies on Cancers and Their Potential Applications

  Yang, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Phosphopyruvate Hydratase 100%
  • Anti-Idiotypic Antibodies 22%
  • Antibodies 17%
  • Single-Chain Antibodies 13%
  • Neoplasms 10%

• Study of Anti-Αlpha-Enolase I Antibodies on Cancers and Their Potential Applications

  Yang, Y. & Leu, S.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Phosphopyruvate Hydratase 100%
  • Anti-Idiotypic Antibodies 22%
  • Antibodies 17%
  • Single-Chain Antibodies 13%
  • Neoplasms 10%

• Study of C3H-Type Zinc-Finger Proteins on the Down-Regulation of Ubiquitination-Mediated Activation of Signal Transduction

  Liang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Ubiquitin 100%
  • Ubiquitination 71%
  • Lysine 32%
  • Zinc Fingers 28%
  • Signal Transduction 25%

• Study of Context Aware Knowledge Supporting Systems---A Case Study of Premature Neonates Care

  Liu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Ero1a on the Roles of Epithelial-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma

  Liang, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Expression and Functional Mechanisms of Histamine N-Methyltransferase (HNMT) in Tumorigenesis and Correlation with Progression in Lung Cancer

  Wang, L., Lee, W., Ho, Y. & Wu, A. T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Lung Neoplasms 43%
  • Carcinogenesis 18%
  • Neoplasms 10%
  • Genes 9%

• Study of Novel Genes Regulated by Aberrant DNA Methylation and Application in Colon Cancer Treatment

  Lin, R. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neoplasm Genes 100%
  • Methylation 83%
  • Taiwan 82%
  • DNA Methylation 81%
  • Colonic Neoplasms 66%

• Study of the mechanism of HPV involved tumorigenesis through Wnt signaling pathway related microRNA regulation

  Cheng, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Catenins 100%
  • MicroRNAs 89%
  • Lung Neoplasms 52%
  • Carcinogenesis 50%
  • Lung 49%

• Study of the Mechanism of HPV Involved Tumorigenesis through Wnt Signaling Pathway Related microRNA Regulation

  Cheng, Y. & Lee, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Catenins 100%
  • MicroRNAs 89%
  • Lung Neoplasms 52%
  • Carcinogenesis 50%
  • Lung 49%

• Study of the Role of L1cam on Neuroendocrine Prostate Cancer Progression

  Hsieh, C.

  8/1/18 → 9/30/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Prostatic Neoplasms 100%
  • Neural Cell Adhesion Molecule L1 91%
  • Castration 16%
  • Phenotype 9%
  • RNA-Binding Proteins 5%

• Study of the Roles of Au-Rich Element (Are)-Binding Proteins and Alternative Polyadenylation on the Tumorigenesis of Human Colorectal Cancer(1/3)

  Liang, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology