Projects per year
- 850 - 900 out of 1,020 results
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Finished
The role of paxillin in tumor malignancy, drug resistance and clinical outcome in lung cancer
Lee, H.
1/1/14 → 12/31/14
Project: A - Government Institution › a - National Health Research Institutes
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Studies of Roles of SIRT7 in Cancer Biology
1/1/14 → 10/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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TMU102-AE1-B29
1/1/14 → 12/30/16
Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty
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103年度第二期癌症研究計畫
1/1/14 → 12/31/14
Project: A - Government Institution › c - Ministry of Health and Welfare
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Dissolution rate improvement of active pharmaceutical ingredients using supercritical fluid technology
1/1/14 → 12/31/14
Project: C - Project of Alliance › j - National Taipei University of Technology
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Preclinical evaluation of novel selective HDAC6 inhibitors for human cancers treatment
1/1/14 → 12/31/14
Project: A - Government Institution › c - Ministry of Health and Welfare
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The role of miR-203 and miR-34a in EGFR activation prostate cancer metastasis
1/1/14 → 12/31/14
Project: A - Government Institution › a - National Health Research Institutes
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利用體外藥物致敏性標的分子篩選結合抗大腸直腸癌藥物之Lipid-base奈米劑型開發
1/1/14 → 12/31/14
Project: A - Government Institution › c - Ministry of Health and Welfare
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TMU102-AE1-B27
1/1/14 → 7/31/15
Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty
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高分子生物用微針製作與細胞及活體實驗
Chang, H.
1/1/14 → 12/31/14
Project: C - Project of Alliance › j - National Taipei University of Technology
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Dissection of Synergistic Involvement among Different Guidance Families in Spinal Motor Neuron Development
12/1/13 → 11/30/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation of Host Factors Affecting the Pathogenesis of Enterovirus 71 in Neuron and Non-Returnable Cells
Lin, J.
12/1/13 → 11/30/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Structural and Functional Studies on the Virulence Regulators SaeR/S in Staphylococcus aureus
12/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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A Preclinical and Clinical Trial Evaluation for an in vitro Diagnostic Kit of Endometriosis (II)
12/1/13 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Potential Application of the Staphylococcus aureus DNA Mimic Protein Saugi in Combating Human Viral Disease
10/1/13 → 9/30/14
Project: A - Government Institution › b - Ministry of Science and Technology
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TELEDERMATOLOGY SOLUTIONS THOUGH MOBILE PHONE
9/1/13 → 8/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Novel Strategies to Target Long-Lived Plasma Cells for Treating Hemophilia a Inhibitors
9/1/13 → 8/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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臺北醫學大學附設醫院之疾病個案收集與建立臺灣人體生物資料庫
8/27/13 → 12/31/13
Project: A - Government Institution › f - Other (Funded by Government)
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Study of the mechanism of HPV involved tumorigenesis through Wnt signaling pathway related microRNA regulation
Cheng, Y.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation of the Functions of Brain Finger Protein, Znf179, in Embryo Development and in Adult Brain
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of LED Light on Porphyromonas gingivalis in Periodontitis for Anti-Inflammation and Alveolar Bone Regeneration
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Molecular mechanisms of alpha9-nicotinic acetylcholine receptor (alpha 9-nAChR)-mediated Trastuzumab (HerceptinR) drug resistance in breast cancer cells
Ho, Y.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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三陰性乳癌周邊微環境之研究平台建立:以玻尿酸合成酉每Ⅲ抑癌作用為例(1/3)
Ho, Y.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Study of Context Aware Knowledge Supporting Systems---A Case Study of Premature Neonates Care
Liu, C.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Functional Characterization of Niemann-Pick Type C2 Protein in Hepatocellular Carcinoma
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Huntingtin-Associated Protein-Regulated Biomarkers in Neurodegenerative Diseases
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Study of Anti-RRM-2 Antibody Drug Generation and Their Inhibitory Mechanisms
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Exploring Biopathways Related to Cancer Based on Differences of Gene Expression between Cancer and Normal Situation
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Emerging Role That Splicing Factor Plays in the Adipose Development
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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晚期乳癌組織中尼古丁受體(α9-nAChR)表現與Trastuzumab (Herceptin®)產生抗藥性之分子機制探討
Ho, Y.
8/1/13 → 7/31/14
Project: B - Project of TMU › i - Other (Funded by TMU)
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Analyses the Role of ADAM9-Hemidesmosome Components Interaction in Malignant Cancer Metastasis and Future Therapeutic Strategy
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Study the Klf10 alters metabolic pathways in genetic-deficient mice and human pancreatic ductal carcinomas
Chang, H.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Analysis and Data Mining of Decision Characteristic of Prehospital Emergency Patients Transport
Hsu, C.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The effect of vascular endothelial growth factor gene polymorphism in the pathogenesis and therapeutic response of pterygium
Cheng, Y.
8/1/13 → 12/31/14
Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital
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大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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探討小泛素蛋白酶Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(1/2)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Prediction of B-Cell Epitopes Using Propensity Scales and Correspondence Analysis
8/1/13 → 10/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Role of Androgen on Breast Cancer Development and Treatment
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Association of Epidermal Growth Factor Receptor mutations with HPV16/18 E6 Oncoprotein Expression in Non-Small Cell Lung Cancer
Lee, H.
8/1/13 → 7/31/14
Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital
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The role of DDX3 in human papillomavirus-infected lung tumorigenesis
Lee, H.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Distribution of the Number of False Discoveries in Genome-Wide Linkage Scan
8/1/13 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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人類乳突病毒導致肺腫瘤化之可能機轉
Cheng, Y.
6/1/13 → 5/31/14
Project: C - Project of Alliance › p - Taipei Medical University Hospital
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晶體性關節炎侵蝕骨頭(蝕骨細胞分化)的分子機制
6/1/13 → 5/31/14
Project: C - Project of Alliance › p - Taipei Medical University Hospital