College of Medical Science and Technology

Projects

Projects per year 2010 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2024

• 72 Active
• 1020 Finished

Projects per year

Search results

• Finished

  The role of paxillin in tumor malignancy, drug resistance and clinical outcome in lung cancer

  Lee, H.

  1/1/14 → 12/31/14

  Project: A - Government Institution › a - National Health Research Institutes

  • Paxillin 100%
  • Lung Neoplasms 60%
  • Gefitinib 30%
  • gemcitabine 26%
  • Neoplasms 18%

• Studies of Roles of SIRT7 in Cancer Biology

  Tsai, Y.

  1/1/14 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • neoplasms 100%
  • neoplasm cells 59%
  • Biological Sciences 47%
  • cancer therapy 31%
  • drug development 27%

• TMU102-AE1-B29

  HuangFu, W.

  1/1/14 → 12/30/16

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 103年度第二期癌症研究計畫

  Yen, Y.

  1/1/14 → 12/31/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Mouth Neoplasms 100%
  • Biomarkers 26%
  • Metagenomics 25%
  • Metabolomics 22%
  • Taiwan 20%

• Dissolution rate improvement of active pharmaceutical ingredients using supercritical fluid technology

  Sheu, M. & Liu, J.

  1/1/14 → 12/31/14

  Project: C - Project of Alliance › j - National Taipei University of Technology

• TMU102-AE1-B16

  Hsieh, C.

  1/1/14 → 12/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Preclinical evaluation of novel selective HDAC6 inhibitors for human cancers treatment

  Pan, S.

  1/1/14 → 12/31/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • ricolinostat 100%
  • Neoplasms 97%
  • Heterografts 90%
  • Investigational New Drug Application 86%
  • Pharmaceutical Preparations 62%

• The role of miR-203 and miR-34a in EGFR activation prostate cancer metastasis

  Liu, Y.

  1/1/14 → 12/31/14

  Project: A - Government Institution › a - National Health Research Institutes

  • Prostatic Neoplasms 100%
  • Protein-Tyrosine Kinases 52%
  • Neoplasm Metastasis 35%
  • erbB-1 Genes 25%
  • Mutation 21%

• 利用體外藥物致敏性標的分子篩選結合抗大腸直腸癌藥物之Lipid-base奈米劑型開發

  Liu, J.

  1/1/14 → 12/31/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

• TMU102-AE1-B27

  Chen, K.

  1/1/14 → 7/31/15

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 高分子生物用微針製作與細胞及活體實驗

  Chang, H.

  1/1/14 → 12/31/14

  Project: C - Project of Alliance › j - National Taipei University of Technology

• Dissection of Synergistic Involvement among Different Guidance Families in Spinal Motor Neuron Development

  Kao, T.

  12/1/13 → 11/30/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Motor Neurons 97%
  • Netrin-1 88%
  • Netrin Receptors 74%
  • Axons 68%
  • Growth Cones 57%

• Investigation of Host Factors Affecting the Pathogenesis of Enterovirus 71 in Neuron and Non-Returnable Cells

  Lin, J.

  12/1/13 → 11/30/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Enterovirus 100%
  • Enterovirus Infections 87%
  • Tropism 44%
  • Small Interfering RNA 31%
  • Taiwan 24%

• Structural and Functional Studies on the Virulence Regulators SaeR/S in Staphylococcus aureus

  Liu, C.

  12/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Staphylococcus aureus 100%
  • virulence 52%
  • immune evasion 23%
  • sepsis (infection) 23%
  • histidine kinase 21%

• A Preclinical and Clinical Trial Evaluation for an in vitro Diagnostic Kit of Endometriosis (II)

  Yang, W.

  12/1/13 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU102-AE1-B12

  Wang, H.

  10/1/13 → 9/30/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Potential Application of the Staphylococcus aureus DNA Mimic Protein Saugi in Combating Human Viral Disease

  Wang, H.

  10/1/13 → 9/30/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • DNA 100%
  • Uracil-DNA Glycosidase 92%
  • DNA Repair Enzymes 83%
  • Neisseria 83%
  • Staphylococcus aureus 77%

• TMU102-AE1-B03

  Hsieh, Y.

  10/1/13 → 9/30/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• TMU102-AE1-B01

  Sung, S.

  10/1/13 → 11/30/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• TELEDERMATOLOGY SOLUTIONS THOUGH MOBILE PHONE

  Li, Y.

  9/1/13 → 8/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mongolia 100%
  • health care workers 57%
  • health science 44%
  • information on patients 15%
  • adequate health care 14%

• Novel Strategies to Target Long-Lived Plasma Cells for Treating Hemophilia a Inhibitors

  Liu, C.

  9/1/13 → 8/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 臺北醫學大學附設醫院之疾病個案收集與建立臺灣人體生物資料庫

  Yen, Y.

  8/27/13 → 12/31/13

  Project: A - Government Institution › f - Other (Funded by Government)

• Study of the mechanism of HPV involved tumorigenesis through Wnt signaling pathway related microRNA regulation

  Cheng, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Catenins 100%
  • MicroRNAs 89%
  • Lung Neoplasms 52%
  • Carcinogenesis 50%
  • Lung 49%

• Investigation of the Functions of Brain Finger Protein, Znf179, in Embryo Development and in Adult Brain

  Lee, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Blood Vessels 100%
  • Embryonic Structures 92%
  • Knockout Mice 77%
  • Spatial Learning 68%
  • BFP ring finger protein 64%

• The Effects of LED Light on Porphyromonas gingivalis in Periodontitis for Anti-Inflammation and Alveolar Bone Regeneration

  Deng, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Porphyromonas gingivalis 100%
  • Light 81%
  • Bone Regeneration 64%
  • Inflammation 47%
  • Alveolar Bone Loss 46%

• The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation

  Liang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Pyroptosis 100%
  • Apoptosis 69%
  • Genes 65%
  • Inflammasomes 60%
  • Cell Proliferation 58%

• Molecular mechanisms of alpha9-nicotinic acetylcholine receptor (alpha 9-nAChR)-mediated Trastuzumab (HerceptinR) drug resistance in breast cancer cells

  Ho, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • MicroRNAs 66%
  • Trastuzumab 62%
  • CP 14 54%
  • Antineoplastic Agents 50%

• 三陰性乳癌周邊微環境之研究平台建立：以玻尿酸合成酉每Ⅲ抑癌作用為例(1/3)

  Ho, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Context Aware Knowledge Supporting Systems---A Case Study of Premature Neonates Care

  Liu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Characterization of Niemann-Pick Type C2 Protein in Hepatocellular Carcinoma

  Liao, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hepatocellular Carcinoma 100%
  • Liver Neoplasms 46%
  • Cholesterol 45%
  • Mitogen-Activated Protein Kinase 1 34%
  • Liver 32%

• Huntingtin-Associated Protein-Regulated Biomarkers in Neurodegenerative Diseases

  Lin, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Proteins 100%
  • Proto-Oncogene Proteins c-bcr 55%
  • Neurodegenerative Diseases 47%
  • Microtubules 39%
  • Calcium 37%

• Study of Anti-RRM-2 Antibody Drug Generation and Their Inhibitory Mechanisms

  Yang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Antibodies 100%
  • Single-Chain Antibodies 93%
  • Anti-Idiotypic Antibodies 60%
  • Diphosphates 47%
  • human RRM2B protein 46%

• Exploring Biopathways Related to Cancer Based on Differences of Gene Expression between Cancer and Normal Situation

  Chiu, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Proteins 100%
  • Gene expression 99%
  • Proteomics 48%
  • Genomics 37%

• The Emerging Role That Splicing Factor Plays in the Adipose Development

  Lin, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • brown adipose tissue 100%
  • adipose tissue 84%
  • insulin receptors 78%
  • adipogenesis 75%
  • energy 49%

• TMU101-AE1-B67

  Wang, W.

  8/1/13 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 晚期乳癌組織中尼古丁受體(α9-nAChR)表現與Trastuzumab (Herceptin®)產生抗藥性之分子機制探討

  Ho, Y.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Analyses the Role of ADAM9-Hemidesmosome Components Interaction in Malignant Cancer Metastasis and Future Therapeutic Strategy

  Sung, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • metastasis 100%
  • integrins 49%
  • neoplasms 44%
  • neoplasm cells 41%
  • neoplasm progression 39%

• Study the Klf10 alters metabolic pathways in genetic-deficient mice and human pancreatic ductal carcinomas

  Chang, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1H-benz(e)inden-3-yl)ethanone 100%
  • Metabolic Networks and Pathways 49%
  • Pancreatic Neoplasms 46%
  • Knockout Mice 45%
  • Insulin Resistance 40%

• Analysis and Data Mining of Decision Characteristic of Prehospital Emergency Patients Transport

  Hsu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Data mining 100%
  • Health insurance 90%
  • Decision making 87%
  • Analytic hierarchy process 67%
  • Health care 61%

• The effect of vascular endothelial growth factor gene polymorphism in the pathogenesis and therapeutic response of pterygium

  Cheng, Y.

  8/1/13 → 12/31/14

  Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • pyrimidin-2-one beta-ribofuranoside 100%
  • Autophagy 29%
  • Hypoxia 16%
  • Autophagic Cell Death 13%
  • Colorectal Neoplasms 12%

• 探討小泛素蛋白酶Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(1/2)

  Chang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prediction of B-Cell Epitopes Using Propensity Scales and Correspondence Analysis

  Su, E. C.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Epitopes 100%
  • Proteins 46%
  • Bioinformatics 24%
  • Cells 16%
  • Binding sites 15%

• Role of Androgen on Breast Cancer Development and Treatment

  Lin, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Androgen 100%
  • Testosterone 31%
  • Signal Transduction 21%
  • Chemopreventive 9%
  • Silencing RNA 8%

• Association of Epidermal Growth Factor Receptor mutations with HPV16/18 E6 Oncoprotein Expression in Non-Small Cell Lung Cancer

  Lee, H.

  8/1/13 → 7/31/14

  Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital

• The role of DDX3 in human papillomavirus-infected lung tumorigenesis

  Lee, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Papillomavirus Infections 100%
  • Cisplatin 96%
  • Lung 86%
  • Neoplasms 63%
  • Gastropoda 47%

• Distribution of the Number of False Discoveries in Genome-Wide Linkage Scan

  Wang, W.

  8/1/13 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Genome 100%
  • Genome-Wide Association Study 51%
  • Technology 48%
  • High-Throughput Nucleotide Sequencing 47%
  • Statistics 37%

• 人類乳突病毒導致肺腫瘤化之可能機轉

  Cheng, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 晶體性關節炎侵蝕骨頭(蝕骨細胞分化)的分子機制

  Liang, Y.

  6/1/13 → 5/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital