College of Medical Science and Technology

Projects

Projects per year 2010 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

• 117 Active
• 1077 Finished

Projects per year

Search results

• Development of Novel Therapeutic Agents for Breast Cancer through Targeting Nicotinic Acetylcholine Receptors.

  Wu, C., Ho, Y. & Lee, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Resistance 100%
  • Nicotine 97%
  • Acute Toxicity 95%
  • Acetylcholine 85%
  • Drug 83%

• Development of a Computerized Adaptive Testing of the Health Literacy in Stroke Rehabilitation.

  Hou, W. & Chen, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Health Literacy 100%
  • Stroke Rehabilitation 86%
  • Psychometrics 23%
  • Stroke 21%
  • Rehabilitation 19%

• Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation---The Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example

  Ho, Y. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Breast Neoplasms 100%
  • Gene Expression 46%
  • Tumor Microenvironment 40%
  • Hyaluronan Synthases 30%
  • Fibroblasts 29%

• The Role of Neuropilin-1 Glycosylation in Galectin-1 Induced Activation of Hepatic Stellate Cells and Liver Fibrosis

  Wu, M. & Yang, W.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Galectin 1 100%
  • Neuropilin-1 68%
  • Liver Cirrhosis 28%
  • Platelet-Derived Growth Factor Receptors 24%
  • thiodigalactoside 12%

• Prediction of Cancer Metastasis Using SVM-Based Model with Quantification of Pathway Changes between Different Disease Statuses

  Chiu, H. & Chang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Support vector machines 100%
  • Gene expression 91%
  • Oncology 55%
  • Proteomics 55%
  • Genomics 43%

• Application of Data Mining Techniques for National Health Insurance Research Database Analysis to Develop Risk Assessment System of Major Postoperative Complications

  Lin, C., Liao, C. & Chiu, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Asthma 100%
  • Postoperative Complications 77%
  • Odds Ratio 41%
  • National Health Programs 27%
  • Mortality 25%

• Gene Knock out Mice Model for Studying the Molecular Mechanisms of Early Onset Breast Tumor Microenvironment Regulation.

  Wu, C., Ho, Y. & Tu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Antitumor 100%
  • Growth Factor 25%
  • Apoptotic 24%
  • Cell Death 23%
  • Hormone 21%

• Role of miR-21 in Regulating TET I-Hydroxymethylcytosine and Chemotherapeutic Response in Colorectal Cancer (II)

  Yang, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

• Translational Investigation for Tea Attenuate Smoking-Induced Disease---Breast Cancer and Atherosclerosis as a Mechanistic Study

  Ho, Y. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Tea 100%
  • Nicotine 26%
  • Capsules 23%
  • Breast Neoplasms 23%
  • Smoking 19%

• HMGA2, a New Target of Thyroid Hormone-Induced Progression in Colorectal Cancers

  Lin, H., Chang, T. & Yen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • AT-Hook Motifs 100%
  • Thyroid Hormones 75%
  • tetraiodothyroacetic acid 70%
  • Colorectal Neoplasms 43%
  • Catenins 31%

• The Synergistic Function of Netrin-1 and Ephrin Signals in Spinal Motor Axon Guidance

  Kao, T. & Hsieh, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Netrin Receptors 100%
  • Netrins 82%
  • Ephrins 75%
  • Motor Neurons 50%
  • Netrin-1 40%

• Disease Trajectories and Its Association with Metabolic Dysfunction of Prostate Cancer Men Following Androgen Deprivation Therapy and the Potential of Pharmacological Medication in Preventing Metastatic Diseases.

  Shao, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

• Crystal Structures and Functional Studies of Novel Glycosyltransferases from Staphylococcus aureus

  Liu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Glycosyltransferases 100%
  • Staphylococcus aureus 64%
  • Fibrin 30%
  • Cathepsin G 22%
  • Minisatellite Repeats 19%

• Characterization of Thalamocortical Dysrhythmia in Mild Traumatic Brain Injury Using Simultaneous Mri and Eeg Measurements and Pre-Clinical N-Acetylcysteine Treatment Response

  Chen, C., Liu, H., Tseng, S., Lane, T. J., Lu, C., Chiang, Y. & Tsai, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Acetylcysteine 44%
  • Post-Concussion Syndrome 17%
  • Neuroimaging 15%
  • Electroencephalography 14%
  • Atrophy 9%

• A Wearable Device Evaluation for Medication Management in Patients Taking Sleep Medicine via Cloud Platform Development( I )

  Li, Y., Jian, W. & Lee, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Sleep 100%
  • Wearable technology 35%
  • Health 28%
  • Education 19%
  • Oximeters 11%

• Age-Related Hearing Loss (Presbycusis)---Cisd2 Deficiency Accelerate the Hearing Defect during Aging Process-Renew

  Chen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Presbycusis 100%
  • Hearing 57%
  • Longevity 37%
  • Inner Ear 22%
  • Cochlea 22%

• The Role of Inflammatory Gene Polymorphisms on Risk of Post-Stroke Vascular Dementia (I)

  Chiou, H., Chi, N., Lin, H., Wu, C., Hsieh, F., Hu, C. & Hsieh, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Stroke 93%
  • Cognitive Dysfunction 89%
  • Blood Vessels 52%
  • Inflammation 36%
  • Whole Exome Sequencing 16%

• Bone-Marrow-Derived Mesenchymal Stem Cells in Prostate Cancer-Induced Bone Remodeling

  Hsieh, C., Chen, K. & Sung, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Adipogenic 100%
  • Osteogenic 37%

• Study of Novel Genes Regulated by Aberrant DNA Methylation and Application in Colon Cancer Treatment

  Lin, R. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Neoplasm Genes 100%
  • Methylation 83%
  • Taiwan 82%
  • DNA Methylation 81%
  • Colonic Neoplasms 66%

• The Effect of Long Acting GnRH Agonist Treatment on Mitochondrial Function

  Tzeng, C., Hsieh, R. & Kao, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • hormone agonists 100%
  • mitochondria 91%
  • pathophysiology 42%
  • granulosa cells 38%
  • agonists 32%

• Neuroprotective Effects of Sig-1R-Znf179-Sp1 Pathway on Brain Injury

  Chang, W. & Chuang, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • sigma-1 receptor 100%
  • Traumatic Brain Injury 50%
  • Hydrogen Peroxide 31%
  • Neuroprotective Agents 19%
  • Wounds and Injuries 12%

• Cocaine Induces Sig-1R Nuclear Envelope Localization to Regulate MAOB Expression by Interacting with Emerin-HDACs Co-Repressor Complex

  Chuang, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • sigma-1 receptor 100%
  • Cocaine 63%
  • Monoamine Oxidase 42%
  • emerin 30%
  • Co-Repressor Proteins 29%

• The Mechanistic Action of DDX3 in Colorectal Tumor Progression

  Lee, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Catenins 100%
  • Drug Resistance 26%
  • Neoplasms 25%
  • Colorectal Neoplasms 22%
  • Carcinogenesis 22%

• Effect of HMGA2 in Chemotherapy Response of Colorectal Cancer Patients with Different APC Status (II)

  Yen, Y., Cheng, Y. & Wei, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

• Study of C3H-Type Zinc-Finger Proteins on the Down-Regulation of Ubiquitination-Mediated Activation of Signal Transduction

  Liang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Ubiquitin 100%
  • Ubiquitination 71%
  • Lysine 32%
  • Zinc Fingers 28%
  • Signal Transduction 25%

• Brain Function for Evaluating Post Stroke Recovery Following Robot-Assisted Gait Training and Transcranial Direct Current Stimulation

  Lai, C., Chen, C., Chen, S., Peng, C., Kang, J. & Lin, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Transcranial Direct Current Stimulation 100%
  • Rehabilitation 95%
  • Stroke 63%
  • Gait 29%
  • Neuroimaging 28%

• Uncovering the Specific Interactions between DNA Mimic Proteins and Their Target DNA Binding Proteins by Structure-Based Studies

  Wang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • DNA 100%
  • Uracil-DNA Glycosidase 61%
  • Proteins 58%
  • Neisseria 55%
  • DNA-Binding Proteins 44%

• RRM2 在帶有不同APC 及k-ras 基因突變情形之大腸直腸癌轉移及治療效果所扮演的角色

  Cheng, Y.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Predicton of MHC Binding and Antigen Processing in T-Cell Epitope Identification

  Su, E. C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Epitopes 100%
  • Antigens 64%
  • Peptides 54%
  • T-cells 40%
  • Vaccines 37%

• Smart Mouth Guard 3D Drug Delivery and Wound Dressing Device Development (Project 1)

  Deng, W. & Ou, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Mouth Protectors 100%
  • Bandages 50%
  • Equipment and Supplies 38%
  • Pharmaceutical Preparations 26%
  • Periodontitis 26%

• Investigate Pathogenic Role of Rheumatoid Arthritis, Sjogren's Syndrome, Systemic Lupus Erythematosus and Its Combined Syndromes from Post-Translational Modification of Novel Synovial Fluid and Serum Proteins---Study of 4-Hydroxy-2-Nonenal Modificatio

  Lin, C. & Chang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • rheumatoid arthritis 100%
  • lupus erythematosus 99%
  • autoantibodies 49%
  • proteins 31%
  • autoimmune diseases 29%

• Characterize the E3 Ligase Activity of Znf179 and Its Effect on the Proteinopathies of TDP-43 Protein

  Huang, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Ubiquitin-Protein Ligases 100%
  • TDP-43 Proteinopathies 61%
  • Amyotrophic Lateral Sclerosis 47%
  • Frontotemporal Lobar Degeneration 36%
  • Proteins 32%

• Targeting Cancer Cell’s Metabolism for Treatment of Human Malignant Glioma

  Lee, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Glioma 100%
  • Anoikis 28%
  • Fenofibrate 26%
  • Thioctic Acid 26%
  • Lipids 25%

• Huntingtin-Associated Protein-Mediated Vesicular Trafficking Biomarkers in Neurodegenerative Diseases

  Lin, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Alzheimer Disease 100%
  • Microtubules 83%
  • Neurodegenerative Diseases 74%
  • Biomarkers 69%
  • Huntingtin Protein 62%

• The Pre-clinical Investigation of the Anticancer Effects of Polysaccharides Extracted from Ulva Prolifera on Colon Cancer

  Deng, W.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Polysaccharide 100%
  • Anticoagulant 14%
  • Nutrient 12%
  • Antineoplastic Agent 10%
  • Antioxidant Agent 8%

• 子宮內膜異位症體外血清診斷試劑開發計畫(1/2)

  Yang, W.

  8/1/15 → 3/31/16

  Project: A - Government Institution › b - National Science and Technology Council

• Design and Preclinical Translation Study of Mixed-Bispecific/Trispecific Antibody for Enhancing Therapeutic Effectiveness of Anticancer Drug-Loaded Pegylated Nanocarriers by Simultaneously Targeting to Tumor Cells and Cancer/Tumor Associated Fibrobla (I)

  Sheu, M., Chuang, K. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Nanocarrier 100%
  • Antigen 77%
  • Tumor Marker 61%
  • Modification 51%
  • Liposome 42%

• Radiogenomics of Malignant Gliomas by Linking Physiological Mr Imaging, Histopathological Patterns, and Genetic Alternations: a Translational Study from Rat to Man

  Chen, C., Tsai, P., Liu, H., Lin, Y. & Chiang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Glioblastoma 100%
  • Glioma 51%
  • Biomarkers 36%
  • Multiparametric Magnetic Resonance Imaging 15%
  • Neoplasms 14%

• Analyses of ADAM9 on Integrin B4 Turnover to Facilitate Prostate Cancer Migration and Invasion

  Sung, S. & Hsieh, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • metastasis 100%
  • integrins 89%
  • neoplasm progression 42%
  • prostatic neoplasms 38%
  • neoplasms 38%

• Identification of Human Viral Micrornas and Its Targets by Using Small RNA Sequencing Data Based on RNA Sequence and Structure Features

  Chang, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • MicroRNAs 100%
  • Forensic Anthropology 14%
  • Databases 13%
  • Viruses 7%
  • Mammals 6%

• Development of Novel Tetracyclic and Heterocyclic Dual Topoisomerases Inhibitors as Anticancer Agents( I )

  Huang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Topoisomerase Inhibitor 100%
  • Antineoplastic Agent 79%
  • Molecule 51%
  • Compound Mobility 45%
  • Anthraquinone 32%

• Construction and Application of Spatio-Temporal Database and Geography Information System for Emergency Medical Care (II)

  Lin, M. & Chiu, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

• The Effectiveness of the Physician-Nurse-Pharmacist Collaboration Model in Medication Reconciliation Using National Health Insurance Pharmacloud in Ambulatory Care

  Hu, S. H., Li, Y., Sheu, S. & Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • medication 100%
  • ambulatory care 45%
  • pharmacist 40%
  • reconciliation 39%
  • physician 33%

• To See Is to Believe- Visualization of the Spectrum on Chronic Kidney Disease (II)

  Jian, W., Li, Y. & Wu, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Health care 100%
  • Data visualization 75%
  • Patient treatment 50%
  • Disease control 49%
  • Health insurance 49%

• Development of Cortical Electrical Stimulation Technique for Improving Neuroplasticity and Motor Function in Parkinsonian Rats

  Hsieh, T., Chiang, Y. & Peng, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

• Repositioning Drug Therapies for Traumatic Brain Injury

  Chiu, W., Chang, C. & Chiang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Traumatic Brain Injury 100%
  • Wounds and Injuries 37%
  • Dipeptidyl-Peptidase IV Inhibitors 33%
  • Incretins 33%
  • Acetylcysteine 28%

• Genomic, Epigenomic and Epiproteomic Analysis of Etk/Bmx Traumatic Brain Injury

  Chen, K., Chiang, Y. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Traumatic Brain Injury 100%
  • Protein Kinases 15%
  • Epigenomics 14%
  • Tec protein-tyrosine kinase 14%
  • Inflammation Mediators 10%

• Activation Autophagy by the Combination of a Histone Deacetylase Inhibitor and Radiation Limits BNIP3 Regulation in Triple-Negative Breast Cancer Cells and Orthotopic Mouse Model

  Chiu, H. & Ho, Y.

  8/1/15 → 6/30/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Triple Negative Breast Neoplasms 100%
  • Histone Deacetylase Inhibitors 97%
  • Ionizing Radiation 42%
  • Autophagy 39%
  • human ERBB2 protein 25%

• Investigate the Biological and Prognostic Association of Annexin A2 in Nasopharyngeal Carcinoma

  Chen, C. & Lee, F.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Annexin A2 100%
  • Nasopharyngeal Carcinoma 85%
  • Annexins 40%
  • DC-specific ICAM-3 grabbing nonintegrin 12%
  • Radiotherapy 10%

• The Effects and Molecular Mechanisms of Phthalates (DEHP 和DBP) on the Mitochondrial Function and Genetic Regulation in Ovarian Granulosa Cells and Mouse Embryo

  Tzeng, C. & Kao, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • phthalates 100%
  • granulosa cells 23%
  • reproductive system 17%
  • mice 14%
  • embryo (animal) 10%