College of Medical Science and Technology

Projects

Projects per year 2010 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2027

• 15 Active
• 1196 Finished

Projects per year

Search results

• Finished

  Investigating potential therapeutic targets of amino acid metabolism in temozolomide -resistance and relapse glioblastoma patients

  Wang, C.-Y. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 建立Rrm2b基因剔除小鼠模式用以研究中樞神經系統星狀膠質細胞增多症

  Chen, Y.-F. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 探討運動神經元SARM1在漸凍人症的神經軸突退化過程中對許旺細胞與肌肉的影響與機轉(1/2)

  Lin, Y.-L. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 開發天然物及其衍生物應用於阿茲海默症之治療(3/3)

  Pan, S.-L. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 設計與優化新穎蛋白質激酶抑制劑應用於胰臟癌之療效與機轉探討(2/3)

  Hsu, K.-C. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 靶向MIR31HG/LncHIFCAR 相關分子網絡在胰腺癌轉移和腫瘤微環境的研究－探討長鏈非編碼RNA-MIR31HG/LncHIFCAR在胰臟癌轉移與腫瘤微環境的交互作用以發展反義寡核苷酸為主的治療策略(1/3)

  Chen, H.-Y. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 標靶整合素αvβ3-FAK訊號網絡的膽管癌診療策略開發-以PRS技術平台優化膽管癌的組合療法(3/3)

  Huang, H.-S. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• Functional Study of Phytoplasma Phyl1 Interacting Proteins Using Structural and Proteomic Approaches – Stage 2 Study( III )

  Wang, H.-C. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 利用臨床表型與穿戴式生理量測資料建立多模態透析病人個人化骨鬆骨折風險預測模型

  Huang, C.-W. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 糖尿病的心血管風險：新穎性抗丙二醛修飾胜肽加成物自體抗體在血漿中的致病角色並導入機器學習以預測第二型糖尿病合併冠狀動脈疾病

  Lin, C.-Y. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 透過調整腫瘤細胞中的類固醇合成至别孕烷醇酮和重新編程脂肪酸代謝來促進自然殺手細胞治療膠質母細胞瘤

  Hsu, T.-I. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 由細菌泛基因體預測與尋找抗藥性細菌的基因體生物標記(2/3)

  Wu, Y.-W. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 脂質薑黃素顆粒(SLCP)在體內對mTOR訊息路徑的作用–尋求以疾病機制為基礎對結節性硬化症(TSC)癲癇的治療策略(3/3)

  Lee, Y.-C. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• TNKS / PI31訊息傳遞路徑在TDP-43相關神經病變中調控蛋白酶體之機制(3/3)

  Huang, C.-C. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 裝載GM-CSF及標靶奈米粒子疫苗之水膠複合系統用於原位募集並活化樹突細胞以增強腫瘤特異性免疫反應達到抑制癌症轉移之功效(3/3)

  Pan, W.-Y. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 以跨世代活體高轉移乳癌模型與全基因組剔除(GeCKO)分析模式探討尿苷雙磷酸葡萄糖醛酸基轉移酶2B7(UGT2B7)標靶抗癌機制

  Lee, C.-H. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 研究介白素-1受體拮抗劑(IL1RN)在胰臟癌的功能(3/3)

  Tsai, Y.-C. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 靶向MIR31HG/LncHIFCAR 相關分子網絡在胰腺癌轉移和腫瘤微環境的研究－探討胰臟癌早期轉移基因-FXYD3於MIR31HG-miR-7-5p/miR-206-FXYD3訊息途徑中調控胰臟癌的轉移與酸性微環境的角色(1/3)

  Lee, K.-H. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 探討TEAD4調控粒線體活性及引發攝護腺癌症的機制(3/5)

  Kung, H.-J. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 抗核酸抗體結構特徵研究應用於系統性紅斑狼瘡檢測

  Lee, C.-C. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• FBXO32和FBXL22透過調節泛素機制以及腫瘤微環境抑制非小細胞肺癌

  Chang, S.-C. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 研發新穎性標的 RNA splicing 抑制劑用於治療消化道癌症之智慧型藥物設計與轉譯研究－探討 DYRK1/CLK 抑制劑於人類消化道癌進行 mRNA splicing 調控機制和治療潛力(1/3)

  Pan, S.-L. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 開發用於中樞非典型畸形/橫紋肌樣瘤治療的潛在標的並探討其在臨床前試驗的應用(2/3)

  Chang, C.-C. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 以定量蛋白質體學方法探討SOAT、油滴以及脂肪細胞分泌因子在大腸癌致病機轉所扮演的角色(2/3)

  Huang, T.-C. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 開發神經內分泌分化前列腺癌之次世代免疫治療(1/3)

  Liu, Y.-N. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 探討site-1蛋白酶抑制劑之抗肝癌分子機轉(2/3)

  Yang, P.-M. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 開發具穿透血腦屏障能力之Class IIa組蛋白去乙醯酶選擇性抑制劑

  Wang, A.H.-J. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 以超高速腦波掃描探討語言發展遲緩幼兒於腦間同步性之神經特徵指標：以親子共讀過程為例

  Lo, Y.-C. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 探討親職壓力對於親代注意力與兒童語言發展遲緩的關聯性

  Lo, Y.-C. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 類澱粉蛋白損害類固醇生成之分子基礎探討

  Kao, S.-H. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 利用in vitro和in vivo平台檢測小泛素化蛋白抗體的專一性及其在臨床檢體之應用

  Chang, C.-C. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 研發新穎性MAPK8抑制劑用於阿茲海默症治療

  HuangFu, W.-C. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 探討新穎TBK1抑制劑對特發性肺纖維化之功效及機轉

  HuangFu, W.-C. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 建立SARS-CoV-2 nsp5內切酶活性冷光檢測平台篩選抗病毒藥物-以Omicron變異株為例

  Lee, C.-H. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 利用鼻腔給藥探討CCL5對成年小鼠神經新生與改善神經功能的效用

  Chou, S.-Y. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 利用YOLO檢測和分類顯微影像中的白血球細胞型態

  Chiu, H.-W. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• CDK Inhibitor-Mediated PD-L1 Upregulation Enhances OC Responsiveness to CAR-Based Regimen Targeting

  Liu, C.-L. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 研究新穎性藥物DYRK1A抑制劑對於阿茲海默症之治療

  Pan, S.-L. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 探討攝護腺癌雄激素剝奪療法導致細胞神經內分泌分化的代謝重編輯機制

  Liu, Y.-N. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• ERO1α在維持癌幹細胞與治療腫瘤細胞的角色

  Liang, Y.-C. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 運用真實世界資料探索H2受體拮抗劑與攝護腺癌的關聯性

  Yang, H.-C. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 探討肝癌細胞長期暴露低劑量塑化劑後對sorafenib感受性的影響及其分子機制

  Liao, Y.-J. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 以活體肺轉移研究平台與全基因剔除模式(GeCKO)探討未分化甲狀腺癌轉移與基因調控-以TNFRSF19、CTDP1基因開發抗甲狀腺癌策略為例

  Lee, C.-H. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 人類卵巢顆粒細胞中粒線體動態平衡對於類固醇荷爾蒙生成的影響

  Kao, S.-H. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 評估納入單基因與多基因變異對於抗核抗體（ANA）在全身性紅斑性狼瘡 （SLE）診斷的影響

  Shao, Y.-H. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 112年度【治療重症地中海貧血與鐮刀型貧血候選藥物AS-28之臨床前試驗(I)】

  Shen, C.-K. (PI)

  7/1/23 → 12/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• 開發治療胰臟癌的新穎性ALK5抑制劑並探討其功效與作用機轉

  Liu, Y.-N. (PI)

  7/1/23 → 2/29/24

  Project: A - Government Institution › b - National Science and Technology Council

• 評估化學療法造成周邊神經病變之新穎模式：3D雙層水凝膠共同培養系統和類器官技術的開發與商轉－評估化學療法造成周邊神經病變之新穎模式：3D雙層水凝膠共同培養系統和類器官技術的開發與商轉

  Sung, S.-Y. (PI)

  6/1/23 → 5/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 新聘教師研究補助

  Lin, Y.-L. (PI)

  5/1/23 → 4/30/24

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 探討前列腺素E2調節之神經細胞活化在神經膠質母細胞瘤產生帝盟多抗性中的角色

  Hsu, T.-I. (PI)

  3/1/23 → 2/29/24

  Project: C - Project of Alliance › o - Chi Mei Medical Center