Additional file 1: Figure S1. Proportion of subjects developing neuropsychiatric symptoms among mTBI and non-mTBI cohorts during the 1-year follow-up period from the index date. Table S1. The allele frequency of single nucleotide polymorphisms (SNPs) in different ethnic groups. Table S2. Basal characteristics of patients with mild traumatic brain injury (mTBI) stratified by sex. Table S3. Sex-stratified analyses for Beck Anxiety Inventory (BAI) score. Table S4. Sex-stratified analyses for Beck Depression Inventory (BDI) score. Table S5. Sex-stratified analyses for Dizziness Handicap Inventory (DHI) score. Table S6. Sex-stratified analyses for Pittsburgh Sleep Quality Index (PSQI) score. Table S7. Single nucleotide polymorphisms (SNPs)-sex interaction analyses for neuropsychiatric symptoms following mild traumatic brain injury (mTBI). Table S8. Expression quantitative trail loci (eQTL) results from Genotype-tissue expression (GTEx). Table S9. Functional annotation by HaploReg V4.1 and RegulomeDB. Table S10. Expression quantitative trait loci (eQTL) results of rs7136446 and rs972936 with insulin-like growth factor 1 (IGF-1) expressions in brain tissues from Genotype-tissue expression (GTEx). Table S11. Association between insulin-like growth factor 1 (IGF-1) expression levels and Alzheimerâ€™s disease (AD) in brain donors with no history of traumatic brain injury (TBI).