Additional file 3: of Xenografting of human umbilical mesenchymal stem cells from Whartonâ s jelly ameliorates mouse spinocerebellar ataxia type 1

Figure S3. Low-magnification images show the anti-calbindin immunostaining for Purkinje cells in cerebellum. The cerebellar slices of all groups were immunostained with anti-calbindin to label Purkinje cells in cerebellum (Column A for Normal group, B for Normal-PBS group, C for SCA1 group, D for SCA1-PBS group, and E for SAC1-HUMSCs group). The lower two panels are magnified images for Lobules III (red arrows) and VI (blue arrows), respectively, in the top panels. The results demonstrated that Purkinje cells were disorganized in alignment and sparse in quantity in Lobules III and VI of the six-month-old SCA1 and SCA1-PBS mice. (PDF 304 kb)