Additional file 3: Figure S2. of Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis

RAB3C overexpression increases exocytosis of colon cancer cells and promotes metastasis through IL-6 secretion. (A) The significant effect of RAB3C overexpressing cell-conditioned medium on the migration ability of parental colon cancer cells indicate that the metastasis-promoting role of RAB3C is exocytosis dependent. (B) Relative IL-6 activity in conditioned medium of CX-1 cells and SW48 cells with or without the exogenous RAB3C gene. The data were the average of three independent experiments and are presented as the mean Âą SEM. The significance of the difference was analyzed using the nonparametric Mann-Whitney U test. (TIFF 28902Â kb)