Figure S2. MEK inhibitors downregulate HDAC inhibitor-induced p-ERK and EGFR expression. (A) PANC-1 cells were treated with 5 μM MPT0E028 or SAHA combined with or without 20 μM PD98059 (PD) for 72 h. The protein expression of p-ERK and EGFR was determined by western blotting. t-ERK was used as an internal control. PANC-1 (B) and BxPC-3 (C) cells were treated with indicated conditions for 48 h to determine EGFR mRNA expression. *P
Date made available | 2019 |
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Publisher | Figshare |
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